HMM Summary Page: TIGR00739

Functionpreprotein translocase, YajC subunit
Gene SymbolyajC
Trusted Cutoff44.20
Domain Trusted Cutoff44.20
Noise Cutoff31.35
Domain Noise Cutoff31.35
Isology Typeequivalog
HMM Length84
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0005887: integral to plasma membrane cellular_component
GO:0009306: protein secretion biological_process
GO:0015450: P-P-bond-hydrolysis-driven protein transmembrane transporter activity molecular_function
AuthorHaft DH
Entry DateFeb 22 2000 11:32AM
Last ModifiedFeb 14 2011 3:27PM
CommentWhile this protein is part of the preprotein translocase in Escherichia coli, it is not essential for viability or protein secretion. The N-terminus region contains a predicted membrane-spanning region followed by a region consisting almost entirely of residues with charged (acidic, basic, or zwitterionic) side chains. This small protein is about 100 residues in length, and is restricted to bacteria; however, this protein is absent from some lineages, including spirochetes and Mycoplasmas.
ReferencesRN [1] RM 97449133 RT The SecDFyajC domain of preprotein translocase controls preprotein movement by regulating SecA membrane cycling. RA Duong F, Wickner W RL EMBO J 1997 Aug 15;16(16):4871-9 RN [2] RM 99043892 RT Cloning and sequencing of yajC and secD homologs of Brucella abortus and demonstration of immune responses to YajC in mice vaccinated with B. abortus RB51. RA Vemulapalli R, Duncan AJ, Boyle SM, Sriranganathan N, Toth TE, Schurig GG RL Infect Immun 1998 Dec;66(12):5684-91
Genome PropertyGenProp0209: Sec system preprotein translocase (HMM)