HMM Summary Page: TIGR00740

FunctiontRNA (cmo5U34)-methyltransferase
Gene SymbolcmoA
Trusted Cutoff193.30
Domain Trusted Cutoff193.30
Noise Cutoff112.00
Domain Noise Cutoff112.00
Isology Typeequivalog
EC Number2.1.1.-
HMM Length239
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0008168: methyltransferase activity molecular_function
AuthorHaft DH
Entry DateFeb 22 2000 11:32AM
Last ModifiedApr 15 2014 12:02PM
CommentThis tRNA methyltransferase is involved, together with cmoB, in preparing the uridine-5-oxyacetic acid (cmo5U) at position 34.
ReferencesRN [1] RM PMID:15383682 RT The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo. RA Nasvall SJ, Chen P, Bjork GR RL RNA. 2004 Oct;10(10):1662-73. RN [2] RM PMID:23676670 RT Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function. RA Kim J, Xiao H, Bonanno JB, Kalyanaraman C, Brown S, Tang X, Al-Obaidi NF, Patskovsky Y, Babbitt PC, Jacobson MP, Lee YS, Almo SC RL Nature. 2013 Jun 6;498(7452):123-6. doi: 10.1038/nature12180. DR HAMAP; MF_01589; 120 of 124
Genome PropertyGenProp1077: tRNA(Pro) cmo5UGG modification (HMM)