|Domain Trusted Cutoff||217.50|
|Domain Noise Cutoff||107.90|
|Mainrole Category||Cell envelope|
|Subrole Category||Biosynthesis and degradation of murein sacculus and peptidoglycan|
|Gene Ontology Term||GO:0009252: peptidoglycan biosynthetic process biological_process|
| ||GO:0030288: outer membrane-bounded periplasmic space cellular_component|
| ||GO:0046677: response to antibiotic biological_process|
| ||GO:0050380: undecaprenyl-diphosphatase activity molecular_function|
|Author||Loftus BJ, Haft DH|
|Entry Date||Mar 2 2000 2:33PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This is a family of small, highly hydrophobic proteins. Overexpression of this protein in Escherichia coli is associated with bacitracin resistance, and the protein was originally proposed to be an undecaprenol kinase and called bacA. It is now known to be an undecaprenyl pyrophosphate phosphatase (EC 184.108.40.206) and is renamed UppP.|
|References||DR InterPro; IPR003824
RT The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity.
RA El Ghachi M, Bouhss A, Blanot D, Mengin-Lecreulx D
RL J Biol Chem. 2004 Jul 16;279(29):30106-13.
RM PMID: 8389741
RT Amplification of the bacA gene confers bacitracin resistance to Escherichia coli.
RA Cain BD, Norton PJ, Eubanks W, Nick HS, Allen CM
RL J Bacteriol 1993 Jun;175(12):3784-9
DR HAMAP; MF_01006; 348 of 485|
|Genome Property||GenProp0971: biosynthesis of undecaprenyl phosphate (Und-P) (HMM)|
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