|Domain Trusted Cutoff||196.90|
|Domain Noise Cutoff||168.60|
|Mainrole Category||Protein synthesis|
|Subrole Category||tRNA and rRNA base modification|
|Gene Ontology Term||GO:0000154: rRNA modification biological_process|
| ||GO:0000179: rRNA (adenine-N6,N6-)-dimethyltransferase activity molecular_function|
|Entry Date||Apr 11 2000 5:53PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||In both E. coli and Saccharomyces cerevisiae, this protein is responsible for
the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes.
A single member of this family is present in each of the first 20 completed microbial genomes.
This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin.
Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase|
DR EXPERIMENTAL; EGAD|18707|EC0051; Escherichia coli; ksgA
DR EXPERIMENTAL; EGAD|56477|YPL266W; Saccharomyces cerevisiae; DIM1
DR COGS; COG0030
RT The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast.
RA Lafontaine D, Delcour J, Glasser AL, Desgres J, Vandenhaute J
RL J Mol Biol 1994 Aug 19;241(3):492-7
DR HAMAP; MF_00607; 470 of 476|
|Genome Property||GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)|
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