| Accession | TIGR00759 |
| Name | aceE |
| Function | pyruvate dehydrogenase (acetyl-transferring), homodimeric type |
| Gene Symbol | aceE |
| Trusted Cutoff | 859.90 |
| Domain Trusted Cutoff | 859.90 |
| Noise Cutoff | 436.60 |
| Domain Noise Cutoff | 436.60 |
| Isology Type | equivalog |
| EC Number | 1.2.4.1 |
| HMM Length | 885 |
| Gene Ontology Term | GO:0004738: pyruvate dehydrogenase activity molecular_function |
| | GO:0006086: acetyl-CoA biosynthetic process from pyruvate biological_process |
| | GO:0045250: cytosolic pyruvate dehydrogenase complex cellular_component |
| Author | Haft DH |
| Entry Date | Jun 13 2000 5:57PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity. |
| References | RN [1]
RM 97334115
RT Molecular characterization of the mde operon involved in L-methionine catabolism of Pseudomonas putida.
RA Inoue H, Inagaki K, Eriguchi SI, Tamura T, Esaki N, Soda K, Tanaka H
RL J Bacteriol 1997 Jun;179(12):3956-62 |
