HMM Summary Page: TIGR00761

Functionacetylglutamate kinase
Gene SymbolargB
Trusted Cutoff151.30
Domain Trusted Cutoff151.30
Noise Cutoff113.20
Domain Noise Cutoff113.20
Isology Typeequivalog_domain
EC Number2.7.2.8
HMM Length231
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryGlutamate family
Gene Ontology TermGO:0003991: acetylglutamate kinase activity molecular_function
GO:0006592: ornithine biosynthetic process biological_process
AuthorHaft DH
Entry DateJun 13 2000 5:57PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes N-acetylglutamate kinases (ArgB) of many prokaryotes and the N-acetylglutamate kinase domains of multifunctional proteins from yeasts. This enzyme is the second step in the "acetylated" ornithine biosynthesis pathway. A related group of enzymes representing the first step of the pathway contain a homologous domain and are excluded from this model.
ReferencesAL clustalw_manual DR EXPERIMENTAL; EGAD|15079|15117; Bacillus stearothermophilus DR EXPERIMENTAL; EGAD|8342|EC3959; Escherichia coli DR EXPERIMENTAL; EGAD|52213|YER069W; Saccharomyces cerevisiae DR OUTGROUP; EGAD|10737|EC2818; N-acetylglutamate synthetase; Escherichia coli RN [1] RM 91301142 RT Determination of amino acid sequences involved in the processing of the ARG5/ARG6 precursor in Saccharomyces cerevisiae. RA Boonchird C, Messenguy F, Dubois E RL Eur J Biochem 1991 Jul 15;199(2):325-35 DR HAMAP; MF_00082; 441 of 446
Genome PropertyGenProp0118: ornithine biosynthesis from glutamate, acetylated branch (HMM)
GenProp0193: lysine biosynthesis via alpha-aminoadipate (AAA pathway) (HMM)