| Accession | TIGR00771 |
| Name | DcuC |
| Function | transporter, anaerobic C4-dicarboxylate uptake C (DcuC) family |
| Trusted Cutoff | 187.00 |
| Domain Trusted Cutoff | 187.00 |
| Noise Cutoff | 148.50 |
| Domain Noise Cutoff | 148.50 |
| Isology Type | subfamily |
| HMM Length | 388 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Carbohydrates, organic alcohols, and acids |
| Gene Ontology Term | GO:0005887: integral to plasma membrane cellular_component |
| | GO:0015556: C4-dicarboxylate transmembrane transporter activity molecular_function |
| | GO:0015740: C4-dicarboxylate transport biological_process |
| Author | Paulsen IT, Saier MH, Loftus BJ |
| Entry Date | Jul 7 2000 1:40PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | These proteins are members of the C4-dicarboxylate Uptake C (DcuC) Family (TC 2.A.61). The only functionally characterized member of this family is the anaerobic C4-dicarboxylate transporter (DcuC) of Escherichia coli. DcuC has 12 GES predicted transmembrane regions, is induced only under anaerobic conditions, and is not repressed by glucose. It may therefore function as a succinate efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB in
catalyzing fumarate-succinate exchange and fumarate uptake. |
| References | SE Ipaulsen
DR URL; http://www-biology.ucsd.edu/~msaier/transport/2_A_61.html |
