| Accession | TIGR00794 |
| Name | kup |
| Function | potassium uptake protein |
| Gene Symbol | kup |
| Trusted Cutoff | 539.60 |
| Domain Trusted Cutoff | 539.60 |
| Noise Cutoff | 444.90 |
| Domain Noise Cutoff | 444.90 |
| Isology Type | equivalog |
| HMM Length | 688 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Cations and iron carrying compounds |
| Gene Ontology Term | GO:0006813: potassium ion transport biological_process |
| | GO:0015079: potassium ion transmembrane transporter activity molecular_function |
| | GO:0016020: membrane cellular_component |
| Author | Paulsen IT, Saier MH, Loftus BJ |
| Entry Date | Jul 7 2000 1:40PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Proteins of the KUP family include the KUP (TrkD) protein of E. coli, a partially sequenced ORF from Lactococcus lactis, high affinity K+ uptake systems (Hak1) of the yeast Debaryomyces occidentalis as well as the fungus, Neurospora crassa, and several homologues in plants. While the E. coli KUP protein is assumed to be a secondary transporter, and uptake is blocked by protonophores such as CCCP (but not arsenate), the energy coupling mechanism has not been defined. However, the N. crassa protein has been shown to be a K+:H+ symporter, establishing that the KUP family consists of secondary carriers. The plant high affinity (20mM) K+ transporter can complement K+ uptake defects in E. coli. |
| References | SE Ipaulsen
DR URL; http://www-biology.ucsd.edu/~msaier/transport/2_A_72.html
DR Interpro; IPR003855
DR PFAM; PF2705
DR HAMAP; MF_01522; 37 of 248 |
