HMM Summary Page: TIGR00798

Functiontricarboxylate carrier
Trusted Cutoff322.80
Domain Trusted Cutoff322.80
Noise Cutoff225.45
Domain Noise Cutoff225.45
Isology Typesubfamily
HMM Length317
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 7 2000 1:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe MTC family consists of a limited number of homologues, all from eukaryotes. A single member of the family has been functionally characterized, the tricarboxylate carrier from rat liver mitochondria. The rat liver mitochondrial tricarboxylate carrier has been reported to transport citrate, cis-aconitate, threo-D-isocitrate, D- and L-tartrate, malate, succinate and phosphoenolpyruvate. It presumably functions by a proton symport mechanism.
ReferencesSE Ipaulsen DR URL; DR Interpro; IPR001993 DR PFAM; PF00153