HMM Summary Page: TIGR00801

Functionuracil-xanthine permease
Trusted Cutoff291.80
Domain Trusted Cutoff291.80
Noise Cutoff202.10
Domain Noise Cutoff202.10
Isology Typesuperfamily
HMM Length415
Mainrole CategoryTransport and binding proteins
Subrole CategoryNucleosides, purines and pyrimidines
Gene Ontology TermGO:0015205: nucleobase transmembrane transporter activity molecular_function
GO:0015851: nucleobase transport biological_process
GO:0016021: integral to membrane cellular_component
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 7 2000 1:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40) Most of the functionally characterized members of the NCS2 family are transporters specific for nucleobases including both purines and pyrimidines. However, two closely related rat members of the family, SVCT1 and SVCT2, localized to different tissues of the body, cotransport L-ascorbate and Na+ with a high degree of specificity and high affinity for the vitamin. The NCS2 family appears to be distantly related to the NCS1 family (TC #2.A.39).
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual