Accession | TIGR00804 |
Name | nupC |
Function | nucleoside transporter, NupC family |
Trusted Cutoff | 442.00 |
Domain Trusted Cutoff | 442.00 |
Noise Cutoff | 200.80 |
Domain Noise Cutoff | 200.80 |
Isology Type | subfamily |
HMM Length | 401 |
Mainrole Category | Transport and binding proteins |
Subrole Category | Nucleosides, purines and pyrimidines |
Gene Ontology Term | GO:0005337: nucleoside transmembrane transporter activity molecular_function |
| GO:0005887: integral to plasma membrane cellular_component |
| GO:0015858: nucleoside transport biological_process |
Author | Paulsen IT, Saier MH, Loftus BJ |
Entry Date | Jul 7 2000 1:41PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41)
Members of the CNT family mediate nucleoside uptake. In bacteria they are energized by H+ symport, but in mammals they are energized by Na+
symport. The different transporters exhibit differing specificities for nucleosides. The E. coli NupC permease transports all nucleosides (both ribo- and deoxyribonucleosides) except hypoxanthine and guanine nucleosides. The B. subtilis NupC is specific for pyrimidine nucleosides (cytidine and uridine and the corresponding deoxyribonucleosides).
The mammalian permease members of the CNT family also exhibit differing specificities. Thus, rats possess at least two NupC homologues, one specific for both purine and pyrimidine nucleosides and one specific for purine nucleosides. At least three paralogues have been characterized from humans.
One human homologue(CNT1) transports pyrimidine nucleosides and adenosine, but deoxyadenosine and guanosine are poor substrates of this permease. Another (CNT2) is selective for purine nucleosides. Alteration of just a few amino acyl residues in TMSs 7 and 8 interconverts their specificities. |
References | A2 hmmalign
SE Ipaulsen
AL clustalw_manual |
Genome Property | GenProp0461: utilization of deoxynucleosides (HMM-CLUST) |