HMM Summary Page: TIGR00805

Functionsodium-independent organic anion transporter
Gene Symboloat
Trusted Cutoff280.00
Domain Trusted Cutoff280.00
Noise Cutoff259.30
Domain Noise Cutoff259.30
Isology Typesubfamily
HMM Length639
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 7 2000 1:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Organo Anion Transporter (OAT) Family (TC 2.A.60) Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual