HMM Summary Page: TIGR00822

FunctionPTS system, mannose/fructose/sorbose family, IIC component
Trusted Cutoff339.85
Domain Trusted Cutoff339.85
Noise Cutoff264.60
Domain Noise Cutoff264.60
Isology Typesubfamily
HMM Length267
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
Gene Ontology TermGO:0008982: protein-N(PI)-phosphohistidine-sugar phosphotransferase activity molecular_function
GO:0009401: phosphoenolpyruvate-dependent sugar phosphotransferase system biological_process
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 25 2000 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentBacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Man (PTS splinter group) family is unique in several respects among PTS permease families. It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine,N-acetylglucosamine, and other sugars. Other members of this family can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the sorbose-specific IIC subunits of this family of PTS transporters.
ReferencesSE ipaulsen DR URL;
Genome PropertyGenProp0119: PTS transport system (HMM)