HMM Summary Page: TIGR00824

FunctionPTS system, mannose/fructose/sorbose family, IIA component
Trusted Cutoff98.35
Domain Trusted Cutoff98.35
Noise Cutoff66.75
Domain Noise Cutoff66.75
Isology Typesubfamily_domain
EC Number2.7.1.69
HMM Length116
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 25 2000 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentBacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIA components.
ReferencesSE ipaulsen DR URL;
Genome PropertyGenProp0119: PTS transport system (HMM)