|Function||sodium/hydrogen exchanger 3|
|Domain Trusted Cutoff||251.25|
|Domain Noise Cutoff||245.60|
|Mainrole Category||Transport and binding proteins|
|Subrole Category||Cations and iron carrying compounds|
|Gene Ontology Term||GO:0005887: integral to plasma membrane cellular_component|
| ||GO:0006814: sodium ion transport biological_process|
| ||GO:0006883: cellular sodium ion homeostasis biological_process|
| ||GO:0006885: regulation of pH biological_process|
| ||GO:0015385: sodium:hydrogen antiporter activity molecular_function|
|Author||Paulsen IT, Saier MH, Loftus BJ|
|Entry Date||Jul 25 2000 6:19PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)
The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.
Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in
(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.
This Hmm is specific for the eukaryotic members members of this family.
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