| Accession | TIGR00840 |
| Name | b_cpa1 |
| Function | sodium/hydrogen exchanger 3 |
| Gene Symbol | nhe-3 |
| Trusted Cutoff | 251.25 |
| Domain Trusted Cutoff | 251.25 |
| Noise Cutoff | 245.60 |
| Domain Noise Cutoff | 245.60 |
| Isology Type | equivalog |
| HMM Length | 559 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Cations and iron carrying compounds |
| Gene Ontology Term | GO:0005887: integral to plasma membrane cellular_component |
| | GO:0006814: sodium ion transport biological_process |
| | GO:0006883: cellular sodium ion homeostasis biological_process |
| | GO:0006885: regulation of pH biological_process |
| | GO:0015385: sodium:hydrogen antiporter activity molecular_function |
| Author | Paulsen IT, Saier MH, Loftus BJ |
| Entry Date | Jul 25 2000 6:19PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)
The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.
Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in
(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.
This Hmm is specific for the eukaryotic members members of this family.
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| References | A2 hmmalign
SE Ipaulsen
AL clustalw_manual
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