| Accession | TIGR00845 |
| Name | caca |
| Function | sodium/calcium exchanger 1 |
| Trusted Cutoff | 679.85 |
| Domain Trusted Cutoff | 679.85 |
| Noise Cutoff | 553.05 |
| Domain Noise Cutoff | 553.05 |
| Isology Type | equivalog |
| HMM Length | 921 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Other |
| Gene Ontology Term | GO:0005432: calcium:sodium antiporter activity molecular_function |
| | GO:0005887: integral to plasma membrane cellular_component |
| | GO:0006814: sodium ion transport biological_process |
| | GO:0006816: calcium ion transport biological_process |
| | GO:0006874: cellular calcium ion homeostasis biological_process |
| | GO:0006883: cellular sodium ion homeostasis biological_process |
| Author | Paulsen IT, Saier MH, Loftus BJ |
| Entry Date | Jul 25 2000 6:19PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)
Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.
All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.
This Hmm is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family
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| References | A2 hmmalign
SE Ipaulsen
AL clustalw_manual
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