| Accession | TIGR00862 |
| Name | O-ClC |
| Function | intracellular chloride channel protein |
| Trusted Cutoff | 358.95 |
| Domain Trusted Cutoff | 358.95 |
| Noise Cutoff | 237.80 |
| Domain Noise Cutoff | 237.80 |
| Isology Type | subfamily |
| HMM Length | 236 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Anions |
| Author | Paulsen IT, Saier MH, Loftus BJ |
| Entry Date | Aug 11 2000 1:26PM |
| Last Modified | Jul 18 2011 3:02PM |
| Comment | The Organellar Chloride Channel (O-ClC) Family (TC 1.A.12)
Proteins of the O-ClC family are voltage-sensitive chloride channels found in intracellular membranes but not the plasma membranes of animal cells. They are
found in human nuclear membranes, and the bovine protein targets to the microsomes, but not the plasma membrane, when expressed in Xenopus laevis oocytes.
These proteins are thought to function in the regulation of the membrane potential and in transepithelial ion absorption and secretion in the kidney. |
| References | A2 hmmalign
SE Ipaulsen
AL clustalw_manual |
