HMM Summary Page: TIGR00928

Functionadenylosuccinate lyase
Gene SymbolpurB
Trusted Cutoff326.20
Domain Trusted Cutoff326.20
Noise Cutoff307.75
Domain Noise Cutoff307.75
Isology Typeequivalog
EC Number4.3.2.2
HMM Length436
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPurine ribonucleotide biosynthesis
Gene Ontology TermGO:0004018: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity molecular_function
GO:0009152: purine ribonucleotide biosynthetic process biological_process
AuthorHaft DH, Durkin S
Entry DateSep 13 2000 5:59PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of adenylosuccinate lyase, the enzyme that catalyzes step 8 in the purine biosynthesis pathway for de novo synthesis of IMP and also the final reaction in the two-step sequence from IMP to AMP.
ReferencesDR EXPERIMENTAL; EGAD|164678|TM1095; Thermotoga maritima DR EXPERIMENTAL; EGAD|14517|EC1131; Escherichia coli DR EXPERIMENTAL; EGAD|2198|2146; Homo sapiens DR OUTGROUP; EGAD|49512|slr1133; argininosuccinate lyase DR OUTGROUP; EGAD|64123|67018; argininosuccinate lyase RM Medline: 92104952 RT Escherichia coli purB gene: cloning, nucleotide sequence, and regulation by purR. RA He B, Smith JM, Zalkin H. RL J Bacteriol. 1992 Jan;174(1):130-6.
Genome PropertyGenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)
GenProp0747: adenosine monophosphate (AMP) biosynthesis from inosine monophosphate (IMP) (HMM)