| Accession | TIGR00973 |
| Name | leuA_bact |
| Function | 2-isopropylmalate synthase |
| Gene Symbol | leuA |
| Trusted Cutoff | 598.70 |
| Domain Trusted Cutoff | 598.70 |
| Noise Cutoff | 597.20 |
| Domain Noise Cutoff | 597.20 |
| Isology Type | equivalog |
| EC Number | 2.3.3.13 |
| HMM Length | 494 |
| Mainrole Category | Amino acid biosynthesis |
| Subrole Category | Pyruvate family |
| Gene Ontology Term | GO:0003852: 2-isopropylmalate synthase activity molecular_function |
| | GO:0009098: leucine biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Sep 29 2000 11:32AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This is the first enzyme of leucine biosynthesis.
A larger family of homologous proteins includes homocitrate synthase, distinct lineages of 2-isopropylmalate synthase, several distinct, uncharacterized, orthologous sets in the Archaea, and other related enzymes. This model describes a family of 2-isopropylmalate synthases found primarily in Bacteria. The homologous families in the Archaea may represent isozymes and/or related enzymes. |
| References |
DR HAMAP; MF_01025; 77 of 96 |
| Genome Property | GenProp0164: leucine biosynthesis from pyruvate and acetyl-CoA (HMM) |
