HMM Summary Page: TIGR00977

Functioncitramalate synthase
Gene SymbolcimA
Trusted Cutoff450.00
Domain Trusted Cutoff450.00
Noise Cutoff325.00
Domain Noise Cutoff325.00
Isology Typeequivalog
EC Number2.3.1.182
HMM Length526
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorHaft DH
Entry DateSep 29 2000 4:43PM
Last ModifiedSep 15 2014 12:45PM
CommentThis model includes GSU1798 and is now known to represent citramalate synthase. Members are related to 2-isopropylmalate synthases and homocitrate synthases but phylogenetically distinct. The role is isoleucine biosynthesis, the first dedicated step.
ReferencesRN [1] RM PMID:18245290 RT Elucidation of an alternate isoleucine biosynthesis pathway in Geobacter sulfurreducens. RA Risso C, Van Dien SJ, Orloff A, Lovley DR, Coppi MV RL J Bacteriol. 2008 Apr;190(7):2266-74. doi: 10.1128/JB.01841-07.
Genome PropertyGenProp0193: lysine biosynthesis via alpha-aminoadipate (AAA pathway) (HMM)