| Accession | TIGR01016 |
| Name | sucCoAbeta |
| Function | succinate-CoA ligase, beta subunit |
| Gene Symbol | sucC |
| Trusted Cutoff | 375.55 |
| Domain Trusted Cutoff | 375.55 |
| Noise Cutoff | 167.75 |
| Domain Noise Cutoff | 167.75 |
| Isology Type | subfamily |
| EC Number | 6.2.1.- |
| HMM Length | 386 |
| Mainrole Category | Energy metabolism |
| Subrole Category | TCA cycle |
| Gene Ontology Term | GO:0004774: succinate-CoA ligase activity molecular_function |
| | GO:0004775: succinate-CoA ligase (ADP-forming) activity molecular_function |
| | GO:0004776: succinate-CoA ligase (GDP-forming) activity molecular_function |
| | GO:0006099: tricarboxylic acid cycle biological_process |
| Author | Haft DH |
| Entry Date | Nov 6 2000 11:33AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model is designated subfamily because it does not discriminate the ADP-forming enzyme ((EC 6.2.1.5) from the GDP_forming (EC 6.2.1.4) enzyme.
The N-terminal half is described by the CoA-ligases HMM (PF00549). The C-terminal half is described by the ATP-grasp HMM (PF02222).
This family contains a split seen both in a maximum parsimony tree (which ignores gaps) and in the gap pattern near position 85 of the seed alignment. Eukaryotic and most bacterial sequences are longer and contain a region similar to TXQTXXXG. Sequences from Deinococcus radiodurans, Mycobacterium tuberculosis, Streptomyces coelicolor, and the Archaea are 6 amino acids shorter in that region and contain a motif resembling [KR]G |
| References | DR COGS; COG0045
DR HAMAP; MF_00558; 358 of 363 |
| Genome Property | GenProp0033: TCA cycle (HMM) |
