Accession | TIGR01065 |
Name | hlyIII |
Function | channel protein, hemolysin III family |
Trusted Cutoff | 172.20 |
Domain Trusted Cutoff | 172.20 |
Noise Cutoff | 28.05 |
Domain Noise Cutoff | 28.05 |
Isology Type | subfamily |
HMM Length | 204 |
Gene Ontology Term | GO:0015267: channel activity molecular_function |
| GO:0019835: cytolysis biological_process |
Author | Haft DH |
Entry Date | Dec 6 2000 1:45PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role. |
References | RN [1]
DR EXPERIMENTAL; EGAD|38000|39576; Bacillus cereus hemolysisn III
RM 97071728
RT Mechanism of action of hemolysin III from Bacillus cereus.
RA Baida GE, Kuzmin NP
RL Biochim Biophys Acta 1996 Oct 23;1284(2):122-4
RN [2]
RM 96106867
RT Molecular cloning of a novel macrophage maturation-associated transcript encoding a protein with several potential transmembrane domains.
RA Rehli M, Krause SW, Schwarzfischer L, Kreutz M, Andreesen R
RL Biochem. Biophys. Res. Commun. 217 (2), 661-667 (1995) |