HMM Summary Page: TIGR01076

Trusted Cutoff39.35
Domain Trusted Cutoff39.35
Noise Cutoff21.95
Domain Noise Cutoff21.95
Isology Typesubfamily
EC Number3.4.22.-
HMM Length136
Mainrole CategoryCell envelope
Subrole CategoryOther
Gene Ontology TermGO:0008233: peptidase activity molecular_function
GO:0045184: establishment of protein localization biological_process
GO:0051605: protein maturation by peptide bond cleavage biological_process
AuthorHaft DH
Entry DateDec 15 2000 4:15PM
Last ModifiedSep 23 2011 9:22AM
CommentThis family includes Staphylococcus aureus sortase, a transpeptidase that attaches surface proteins by the Thr of an LPXTG motif to the cell wall. It also includes a protein required for correct assembly of an LPXTG-containing fimbrial protein, a set of homologous proteins from Streptococcus pneumoniae, in which LPXTG proteins are common. However, related proteins are found in Bacillus subtilis and Methanobacterium thermoautotrophicum, in which LPXTG-mediated cell wall attachment is not known.
ReferencesRN [1] RM 99357874 RT Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. RA Mazmanian SK, Liu G, Ton-That H, Schneewind O. RL Science 1999 Jul 30;285(5428):760-3
Genome PropertyGenProp0626: protein sorting system, sortase type, LPXTG/SrtA class (HMM)