| Accession | TIGR01110 |
| Name | mdcA |
| Function | malonate decarboxylase, alpha subunit |
| Gene Symbol | mdcA |
| Trusted Cutoff | 789.15 |
| Domain Trusted Cutoff | 789.15 |
| Noise Cutoff | 313.85 |
| Domain Noise Cutoff | 313.85 |
| Isology Type | equivalog |
| HMM Length | 543 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Cations and iron carrying compounds |
| Gene Ontology Term | GO:0006810: transport biological_process |
| | GO:0015451: decarboxylation-driven active transmembrane transporter activity molecular_function |
| Author | Ujwal ML, Haft DH, Paulsen IT |
| Entry Date | Jan 9 2001 4:09PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model describes malonate decarboxylase alpha subunit, from both the water-soluble form as found in Klebsiella pneumoniae and the form couple to sodium ion pumping in Malonomonas rubra. Malonate decarboxylase Na+ pump is the paradigm of the family of Na+ transport decarboxylases. Essentially, it couples the energy derived from decarboxylation of a carboxylic acid substrate to move Na+ ion across the bilayer. Functional malonate decarboylase is a multi subunit protein. The alpha subunit enzymatically performs the transfer of malonate (substrate) to an acyl carrier protein subunit for subsequent decarboxylation, hence the name: acetyl-S-acyl carrier protein:malonate carrier protein-SH transferase. |
| References | RN [1]
RM PMID: 11902724
RT Enzymic and genetic basis for bacterial growth on malonate.
RA Dimroth P, Hilbi H
RL Mol Microbiol. 1997 Jul;25(1):3-10. |
| Genome Property | GenProp0674: malonate decarboxylase (HMM) |
