HMM Summary Page: TIGR01124

Functionthreonine ammonia-lyase, biosynthetic
Gene SymbolilvA
Trusted Cutoff411.30
Domain Trusted Cutoff411.30
Noise Cutoff325.50
Domain Noise Cutoff325.50
Isology Typeequivalog
EC Number4.3.1.19
HMM Length499
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryPyruvate family
Gene Ontology TermGO:0004794: L-threonine ammonia-lyase activity molecular_function
GO:0009097: isoleucine biosynthetic process biological_process
AuthorHaft DH
Entry DateJan 15 2001 11:55AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes a form of threonine ammonia-lyase, a pyridoxal-phosphate dependent enzyme, with two copies of the threonine dehydratase C-terminal domain (Pfam:PF00585). Members with known function participate in isoleucine biosynthesis and are inhibited by isoleucine. Alternate name: threonine deaminase, threonine dehydratase. Forms scoring between the trusted and noise cutoff tend to branch with this subgroup of threonine ammonia-lyase phylogenetically but have only a single copy of the C-terminal domain.
Genome PropertyGenProp0162: isoleucine biosynthesis from threonine and pyruvate (HMM)