HMM Summary Page: TIGR01143

FunctionUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Gene SymbolmurF
Trusted Cutoff288.60
Domain Trusted Cutoff288.60
Noise Cutoff233.90
Domain Noise Cutoff233.90
Isology Typesubfamily
EC Number6.3.2.10
HMM Length418
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
Gene Ontology TermGO:0009252: peptidoglycan biosynthetic process biological_process
GO:0047480: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity molecular_function
AuthorDodson RJ, Haft DH
Entry DateFeb 2 2001 5:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ.
Genome PropertyGenProp0158: peptidoglycan(murein) biosynthesis (HMM)