| Accession | TIGR01162 |
| Name | purE |
| Function | phosphoribosylaminoimidazole carboxylase, catalytic subunit |
| Gene Symbol | purE |
| Trusted Cutoff | 149.60 |
| Domain Trusted Cutoff | 149.60 |
| Noise Cutoff | 62.25 |
| Domain Noise Cutoff | 62.25 |
| Isology Type | equivalog_domain |
| EC Number | 4.1.1.21 |
| HMM Length | 156 |
| Mainrole Category | Purines, pyrimidines, nucleosides, and nucleotides |
| Subrole Category | Purine ribonucleotide biosynthesis |
| Gene Ontology Term | GO:0004638: phosphoribosylaminoimidazole carboxylase activity molecular_function |
| | GO:0009152: purine ribonucleotide biosynthetic process biological_process |
| | GO:0009320: phosphoribosylaminoimidazole carboxylase complex cellular_component |
| Author | Haft DH |
| Entry Date | Feb 6 2001 12:09PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. This model represents PurK, an N5-CAIR mutase. |
| References | DR SWISSPROT; P09028; PUR6_ECOLI
RM 10074353
RT Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase.
RA Meyer E, Kappock TJ, Osuji C, Stubbe J
RL Biochemistry 1999 Mar 9;38(10):3012-8 |
| Genome Property | GenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM) |
