Accession | TIGR01167 |
Name | LPXTG_anchor |
Function | LPXTG cell wall anchor domain |
Trusted Cutoff | 15.90 |
Domain Trusted Cutoff | 15.90 |
Noise Cutoff | 15.70 |
Domain Noise Cutoff | 15.70 |
Isology Type | domain |
HMM Length | 34 |
Mainrole Category | Cell envelope |
Subrole Category | Other |
Gene Ontology Term | GO:0009986: cell surface cellular_component |
Author | Haft DH |
Entry Date | Feb 12 2001 10:54AM |
Last Modified | Mar 20 2012 5:03PM |
Comment | This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive.
A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. |
References | RM 10754567
RT Sortase: the surface protein anchoring transpeptidase and the LPXTG motif.
RA Novick RP
RL Trends Microbiol 2000 Apr;8(4):148-51 |
Genome Property | GenProp0626: protein sorting system, sortase type, LPXTG/SrtA class (HMM) |