|Function||LPXTG cell wall anchor domain|
|Domain Trusted Cutoff||15.90|
|Domain Noise Cutoff||15.70|
|Mainrole Category||Cell envelope|
|Gene Ontology Term||GO:0009986: cell surface cellular_component|
|Entry Date||Feb 12 2001 10:54AM|
|Last Modified||Mar 20 2012 5:03PM|
|Comment||This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive.
A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region.|
RT Sortase: the surface protein anchoring transpeptidase and the LPXTG motif.
RA Novick RP
RL Trends Microbiol 2000 Apr;8(4):148-51|
|Genome Property||GenProp0626: protein sorting system, sortase type, LPXTG/SrtA class (HMM)|
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