HMM Summary Page: TIGR01187

Functionpolyamine ABC transporter, ATP-binding protein
Trusted Cutoff355.60
Domain Trusted Cutoff355.60
Noise Cutoff349.95
Domain Noise Cutoff349.95
Isology Typesubfamily
EC Number3.6.3.31
HMM Length325
Mainrole CategoryTransport and binding proteins
Subrole CategoryAmino acids, peptides and amines
Gene Ontology TermGO:0005524: ATP binding molecular_function
GO:0009898: internal side of plasma membrane cellular_component
GO:0015417: polyamine-transporting ATPase activity molecular_function
GO:0015846: polyamine transport biological_process
GO:0055052: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing cellular_component
AuthorUjwal ML, Paulsen IT
Entry DateMar 4 2001 10:54PM
Last ModifiedDec 21 2011 12:51PM
CommentThis model describes spermidine/putrescine ABC transporter, ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. Polyamines like spermidine and putrescine play vital role in cell proliferation, differentiation, and ion homeostasis. The concentration of polyamines within the cell are regulated by biosynthesis, degradation and transport (uptake and efflux included).
ReferencesDR HAMAP; MF_01726; 93 of 157