| Accession | TIGR01207 |
| Name | rmlA |
| Function | glucose-1-phosphate thymidylyltransferase |
| Gene Symbol | rfbA |
| Trusted Cutoff | 360.65 |
| Domain Trusted Cutoff | 360.65 |
| Noise Cutoff | 189.50 |
| Domain Noise Cutoff | 189.50 |
| Isology Type | equivalog |
| EC Number | 2.7.7.24 |
| HMM Length | 286 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Gene Ontology Term | GO:0008879: glucose-1-phosphate thymidylyltransferase activity molecular_function |
| | GO:0009243: O antigen biosynthetic process biological_process |
| | GO:0019305: dTDP-rhamnose biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Mar 21 2001 2:37PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Alternate name: dTDP-D-glucose synthase
homotetramer
This HMM describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. |
| References | DR EXPERIMENTAL; EGAD|17315; Salmonella enterica
DR EXPERIMENTAL; OMNI|NT03PA5970; Pseudomonas aeruginosa
DR COGS; COG1209 |
| Genome Property | GenProp0950: 4,6-dideoxy-4-oxo-dTDP-D-glucose biosynthesis from glucose-1-phosphate (HMM) |
| | GenProp0912: Leptospira exopolysaccharide biosynthesis clusters (HMM-CLUST) |
