HMM Summary Page: TIGR01223

Functionphosphomevalonate kinase
Trusted Cutoff188.15
Domain Trusted Cutoff188.15
Noise Cutoff31.35
Domain Noise Cutoff31.35
Isology Typeequivalog
EC Number2.7.4.2
HMM Length185
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryOther
Gene Ontology TermGO:0004631: phosphomevalonate kinase activity molecular_function
GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway biological_process
AuthorHaft DH
Entry DateMay 3 2001 4:12PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found. One is this type, found in animals. The other is the ERG8 type, found in plants and fungi (TIGR01219) and in Gram-positive bacteria (TIGR01220).
ReferencesRM 11243736 RT Nonorthologous gene displacement of phosphomevalonate kinase. RA Houten SM, Waterham HR. RL Mol Genet Metab 2001 Mar;72(3):273-6
Genome PropertyGenProp0047: IPP biosynthesis via mevalonate (HMM)