| Accession | TIGR01246 |
| Name | dapE_proteo |
| Function | succinyl-diaminopimelate desuccinylase |
| Gene Symbol | dapE |
| Trusted Cutoff | 361.80 |
| Domain Trusted Cutoff | 361.80 |
| Noise Cutoff | 192.30 |
| Domain Noise Cutoff | 192.30 |
| Isology Type | equivalog |
| EC Number | 3.5.1.18 |
| HMM Length | 370 |
| Mainrole Category | Amino acid biosynthesis |
| Subrole Category | Aspartate family |
| Gene Ontology Term | GO:0009014: succinyl-diaminopimelate desuccinylase activity molecular_function |
| | GO:0009089: lysine biosynthetic process via diaminopimelate biological_process |
| Author | Haft DH |
| Entry Date | May 16 2001 11:09AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes a proteobacterial subset of succinyl-diaminopimelate desuccinylases. An experimentally confirmed Gram-positive lineage succinyl-diaminopimelate desuccinylase has been described for Corynebacterium glutamicum (SP:Q59284), and a neighbor-joining tree shows the seed members, SP:Q59284, and putative archaeal members such as TrEMBL:O58003 in a single clade. However, the archaeal members differ substantially, share a number of motifs with acetylornithine deacetylases rather than succinyl-diaminopimelate desuccinylases, and are not taken as trusted examples of succinyl-diaminopimelate desuccinylases. This model is limited to proteobacterial members for this reason. |
| Genome Property | GenProp0786: lysine biosynthesis via diaminopimelate (DAP), succinylated branch (HMM) |
