Accession | TIGR01247 |
Name | drrB |
Function | daunorubicin resistance ABC transporter membrane protein |
Trusted Cutoff | 223.05 |
Domain Trusted Cutoff | 223.05 |
Noise Cutoff | 126.20 |
Domain Noise Cutoff | 126.20 |
Isology Type | subfamily |
HMM Length | 236 |
Mainrole Category | Transport and binding proteins |
Subrole Category | Other |
Gene Ontology Term | GO:0005887: integral to plasma membrane cellular_component |
| GO:0043190: ATP-binding cassette (ABC) transporter complex cellular_component |
| GO:0043215: daunorubicin transport biological_process |
| GO:0043216: daunorubicin-transporting ATPase activity molecular_function |
Author | Ujwal ML, Paulsen IT |
Entry Date | May 16 2001 5:16PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This model describes daunorubicin resistance ABC transporter, membrane associated protein in bacteria and archaea. The protein associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. |