| Accession | TIGR01253 |
| Name | thiP |
| Function | thiamine/thiamine pyrophosphate ABC transporter, permease protein |
| Gene Symbol | thiP |
| Trusted Cutoff | 395.10 |
| Domain Trusted Cutoff | 395.10 |
| Noise Cutoff | 234.10 |
| Domain Noise Cutoff | 234.10 |
| Isology Type | equivalog |
| HMM Length | 519 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Other |
| Gene Ontology Term | GO:0005887: integral to plasma membrane cellular_component |
| | GO:0015619: thiamine pyrophosphate-transporting ATPase activity molecular_function |
| | GO:0015888: thiamine transport biological_process |
| | GO:0030974: thiamine pyrophosphate transport biological_process |
| | GO:0048502: thiamine-transporting ATPase activity molecular_function |
| | GO:0055052: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing cellular_component |
| Author | Ujwal ML, Haft DH, Paulsen IT |
| Entry Date | May 22 2001 3:45PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | The model describes thiamine ABC transporter, permease protein in bacteria. The protein belongs to the larger ABC transport system. It consists of atleast three components: the inner mebrane permease; thiamine binding protein; an ATP-binding subunit. It has been experimentally demonstrated that the mutants in the various steps in the de novo synthesis of the thiamine and the biologically active form, namely thiamine pyrophosphate can be exogenously supplemented with thiamine, thiamine monophosphate (TMP) or thiamine pyrophosphate (TPP). |
| References | RM 98204886
RT thiBPQ encodes an ABC transporter required for transport of thiamine and thiamine pyrophosphate in Salmonella typhimurium.
RA Webb E, Claas K, Downs D.
RL J Biol Chem 1998 Apr 10;273(15):8946-50 |
| Genome Property | GenProp0252: thiamine/TPP ABC transporter ThiBPQ (HMM) |
