HMM Summary Page: TIGR01258

Functionphosphoglycerate mutase 1 family
Trusted Cutoff81.70
Domain Trusted Cutoff81.70
Noise Cutoff72.95
Domain Noise Cutoff72.95
Isology Typesubfamily
HMM Length245
AuthorHaft DH
Entry DateMay 24 2001 11:13AM
Last ModifiedFeb 14 2011 3:27PM
CommentMost members of this family are phosphoglycerate mutase (EC This enzyme interconverts 2-phosphoglycerate and 3-phosphoglycerate. The enzyme is transiently phosphorylated on an active site histidine by 2,3-diphosphoglyerate, which is both substrate and product. Some members of this family have are phosphoglycerate mutase as a minor activity and act primarily as a bisphoglycerate mutase, interconverting 2,3-diphosphoglycerate and 1,3-diphosphoglycerate (EC This HMM is designated as a subfamily for this reason. The second and third paralogs in S. cerevisiae are somewhat divergent and apparently inactive (see PUBMED:9544241) but are also part of this subfamily phylogenetically.
ReferencesDR COGS; COG0588 RM 9544241 DR HAMAP; MF_01039; 267 of 272
Genome PropertyGenProp0691: glycolysis (HMM)