HMM Summary Page: TIGR01263

Function4-hydroxyphenylpyruvate dioxygenase
Gene SymbolhppD
Trusted Cutoff277.00
Domain Trusted Cutoff277.00
Noise Cutoff93.60
Domain Noise Cutoff93.60
Isology Typeequivalog
EC Number1.13.11.27
HMM Length353
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0003868: 4-hydroxyphenylpyruvate dioxygenase activity molecular_function
GO:0006559: L-phenylalanine catabolic process biological_process
GO:0006572: tyrosine catabolic process biological_process
AuthorHaft DH
Entry DateJun 1 2001 11:08AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein oxidizes 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is hemolytic (see PMID:8000039). In some bacterial species, this enzyme has been studied as a hemolysin.
ReferencesDR EXPERIMENTAL; EGAD|22485; Streptomyces avermitilis
Genome PropertyGenProp0139: degradation of tyrosine via homogentisate (HMM)