HMM Summary Page: TIGR01267

Gene SymbolphhA
Trusted Cutoff264.75
Domain Trusted Cutoff264.75
Noise Cutoff182.45
Domain Noise Cutoff182.45
Isology Typeequivalog
EC Number1.14.16.1
HMM Length248
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0004505: phenylalanine 4-monooxygenase activity molecular_function
GO:0006559: L-phenylalanine catabolic process biological_process
AuthorHaft DH
Entry DateJun 5 2001 11:14AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes the smaller, monomeric form of phenylalanine-4-hydroxylase, as found in a small number of Gram-negative bacteria. The enzyme irreversibly converts phenylalanine to tryosine and is known to be the rate-limiting step in phenylalanine catabolism in some systems. This family is of biopterin and metal-dependent hydroxylases is related to a family of longer, multimeric aromatic amino acid hydroxylases that have additional N-terminal regulatory sequences. These include tyrosine 3-monooxygenase, phenylalanine-4-hydroxylase, and tryptophan 5-monoxygenase.
ReferencesDR EXPERIMENTAL; SP|P30967; Chromobacterium violaceum DR EXPERIMENTAL; SP:P43334; Pseudomonas aeruginosa
Genome PropertyGenProp0045: tyrosine biosynthesis from chorismate (HMM)