| Accession | TIGR01271 |
| Name | CFTR_protein |
| Function | cystic fibrosis transmembrane conductor regulator (CFTR) |
| Trusted Cutoff | 1761.20 |
| Domain Trusted Cutoff | 1761.20 |
| Noise Cutoff | 1208.30 |
| Domain Noise Cutoff | 1208.30 |
| Isology Type | equivalog |
| EC Number | 3.6.3.49 |
| HMM Length | 1490 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Anions |
| Gene Ontology Term | GO:0005260: channel-conductance-controlling ATPase activity molecular_function |
| | GO:0030321: transepithelial chloride transport biological_process |
| Author | Loftus BJ, Ujwal ML, Paulsen IT |
| Entry Date | Jun 6 2001 11:20AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. |
