HMM Summary Page: TIGR01302

Functioninosine-5'-monophosphate dehydrogenase
Gene SymbolguaB
Trusted Cutoff481.50
Domain Trusted Cutoff481.50
Noise Cutoff303.25
Domain Noise Cutoff303.25
Isology Typeequivalog
EC Number1.1.1.205
HMM Length450
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPurine ribonucleotide biosynthesis
Gene Ontology TermGO:0003938: IMP dehydrogenase activity molecular_function
GO:0009152: purine ribonucleotide biosynthetic process biological_process
AuthorHaft DH
Entry DateJul 6 2001 12:51PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes IMP dehydrogenase, an enzyme of GMP biosynthesis. This form contains two CBS domains. This HMM describes a rather tightly conserved cluster of IMP dehydrogenase sequences, many of which are characterized. The model excludes two related families of proteins proposed also to be IMP dehydrogenases, but without characterized members. These are related families are the subject of separate models.
ReferencesDR; PFAM; PF00571; CBS (two copies) DR; PFAM; PF00478; IMPDH_C DR; PFAM; PF01574; IMPDH_N DR; EXPERIMENTAL; SP|P50097; Tritrichomonas foetus DR; EXPERIMENTAL; SP|P50099; Streptococcus pyogenes DR; EXPERIMENTAL; GP|146275; Homo sapiens
Genome PropertyGenProp0697: guanine monophosphate (GMP) biosynthesis from inosine monophosphate (IMP) (HMM)