|Function||malate dehydrogenase (acceptor)|
|Domain Trusted Cutoff||549.95|
|Domain Noise Cutoff||197.40|
|Mainrole Category||Energy metabolism|
|Subrole Category||TCA cycle|
|Gene Ontology Term||GO:0006099: tricarboxylic acid cycle biological_process|
| ||GO:0008924: malate dehydrogenase (quinone) activity molecular_function|
|Entry Date||Aug 6 2001 2:02PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This membrane-associated enzyme is an alternative to the better-known NAD-dependent malate dehydrogenase as part of the TCA cycle. The reduction of a quinone rather than NAD+ makes the reaction essentially irreversible in the direction of malate oxidation to oxaloacetate. Both forms of malate dehydrogenase are active in E. coli; disruption of this form causes less phenotypic change. In some bacteria, this form is the only or the more important malate dehydrogenase.|
RT Functions of the membrane-associated and cytoplasmic malate dehydrogenases in the citric acid cycle of Escherichia coli.
RA van der Rest ME, Frank C, Molenaar D.
RL J Bacteriol 2000 Dec;182(24):6892-9RM 11092847
DR HAMAP; MF_00212; 117 of 129|
|Genome Property||GenProp0033: TCA cycle (HMM)|
© J. Craig Venter Institute | Privacy Statement | Data Disclaimer