HMM Summary Page: TIGR01358

Function3-deoxy-7-phosphoheptulonate synthase
Trusted Cutoff614.70
Domain Trusted Cutoff614.70
Noise Cutoff464.35
Domain Noise Cutoff464.35
Isology Typeequivalog
EC Number2.5.1.54
HMM Length443
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAromatic amino acid family
Gene Ontology TermGO:0003849: 3-deoxy-7-phosphoheptulonate synthase activity molecular_function
GO:0009423: chorismate biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 9 2001 3:36PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the class II family of 3-deoxy-7-phosphoheptulonate synthase, aka phospho-2-dehydro-3-deoxyheptonate aldolase, as found in plants and some bacteria. It shows some similarity to the class I family found in many bacteria. The enzyme catalyzes the first of 7 steps in the biosynthesis of chorismate, that last common precursor of all three aromatic amino acids. Homologs scoring between trusted and noise cutoff include proteins involved in antibiotic biosynthesis; one example is active as this enzyme, while another acts on an amino analog.
ReferencesDR COGS; COG3200 DR EXPERIMENTAL; SP|P80574; Streptomyces coelicolor DR EXPERIMENTAL; SP|P29976; Arabidopsis thaliana; 1 DR EXPERIMENTAL; SP|Q00218; Arabidopsis thaliana; 2
Genome PropertyGenProp0001: chorismate biosynthesis via shikimate (HMM)