HMM Summary Page: TIGR01361

Function3-deoxy-7-phosphoheptulonate synthase
Gene SymbolaroF
Trusted Cutoff267.75
Domain Trusted Cutoff267.75
Noise Cutoff132.85
Domain Noise Cutoff132.85
Isology Typeequivalog_domain
EC Number2.5.1.54
HMM Length260
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAromatic amino acid family
Gene Ontology TermGO:0003849: 3-deoxy-7-phosphoheptulonate synthase activity molecular_function
GO:0009423: chorismate biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 19 2001 2:32PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes one of at least three types of phospho-2-dehydro-3-deoxyheptonate aldolase (DAHP synthase). This enzyme catalyzes the first of 7 steps in the biosynthesis of chorismate, that last common precursor of all three aromatic amino acids and of PABA, ubiquinone and menaquinone. Some members of this family, including an experimentally characterized member from Bacillus subtilis, are bifunctional, with a chorismate mutase domain N-terminal to this region. The member of this family from Synechocystis PCC 6803, CcmA, was shown to be essential for carboxysome formation. However, no other candidate for this enzyme is present in that species, chorismate biosynthesis does occur, other species having this protein lack carboxysomes but appear to make chorismate, and a requirement of CcmA for carboxysome formation does not prohibit a role in chorismate biosynthesis.
ReferencesDR SP:P39912; Bacillus subtilis
Genome PropertyGenProp0001: chorismate biosynthesis via shikimate (HMM)