HMM Summary Page: TIGR01363
Accession | TIGR01363 |
Name | strep_his_triad |
Function | streptococcal histidine triad protein |
Trusted Cutoff | 33.00 |
Domain Trusted Cutoff | 33.00 |
Noise Cutoff | 25.00 |
Domain Noise Cutoff | 25.00 |
Isology Type | subfamily_domain |
HMM Length | 348 |
Mainrole Category | Cellular processes |
Subrole Category | Pathogenesis |
Author | Haft DH |
Entry Date | Oct 23 2001 8:27AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM represents the N-terminal half of a family of Streptococcal proteins that contain a signal peptide and then up to five repeats of a region that includes a His-X-X-His-X-His (histidine triad) motif. Three repeats are found in the seed alignment. Additional copies in more poorly conserved regions can be detected because this is a fragment-mode HMM. Members of this family from Streptococcus pneumoniae are suggested to cleave human C3, and the member PhpA has been shown in vaccine studies to be a protective antigen in mice. |
References | RM 11349048 RT Recombinant PhpA protein, a unique histidine motif-containing protein from Streptococcus pneumoniae, protects mice against intranasal pneumococcal challenge. RA Zhang Y, Masi AW, Barniak V, Mountzouros K, Hostetter MK, Green BA RL Infect Immun 2001 Jun;69(6):3827-36 |