HMM Summary Page: TIGR01368

Functioncarbamoyl-phosphate synthase, small subunit
Gene SymbolcarA
Trusted Cutoff307.35
Domain Trusted Cutoff307.35
Noise Cutoff133.55
Domain Noise Cutoff133.55
Isology Typeequivalog_domain
EC Number6.3.5.5
HMM Length361
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPyrimidine ribonucleotide biosynthesis
Gene Ontology TermGO:0004088: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity molecular_function
GO:0005951: carbamoyl-phosphate synthase complex cellular_component
GO:0009220: pyrimidine ribonucleotide biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 29 2001 11:17AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the whole of the small chain of the glutamine-dependent form (EC of carbamoyl phosphate synthase, CPSase II. The C-terminal domain has glutamine amidotransferase activity. Note that the sequence from the mammalian urea cycle form has lost the active site Cys, resulting in an ammonia-dependent form, CPSase I (EC CPSases of pyrimidine biosynthesis, arginine biosynthesis, and the urea cycle may be encoded by one or by several genes, depending on the species.
ReferencesDR EXCEPTION; SP|P31327; EC (no GATase activity) DR HAMAP; MF_01209; 131 of 131
Genome PropertyGenProp0187: pyrimidine (uridine-5'-phosphate) de novo biosynthesis (HMM)