HMM Summary Page: TIGR01379

Functionthiamine-phosphate kinase
Gene SymbolthiL
Trusted Cutoff184.15
Domain Trusted Cutoff184.15
Noise Cutoff113.70
Domain Noise Cutoff113.70
Isology Typeequivalog
EC Number2.7.4.16
HMM Length320
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryThiamine
Gene Ontology TermGO:0009030: thiamine-phosphate kinase activity molecular_function
GO:0009228: thiamine biosynthetic process biological_process
AuthorHaft DH
Entry DateNov 15 2001 3:23PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes thiamine-monophosphate kinase, an enzyme that converts thiamine monophosphate into thiamine pyrophosphate (TPP, coenzyme B1), an enzyme cofactor. Thiamine monophosphate may be derived from de novo synthesis or from unphosphorylated thiamine, known as vitamin B1. Proteins scoring between the trusted and noise cutoff for this model include short forms from the Thermoplasmas (which lack the N-terminal region) and a highly derived form from Campylobacter jejuni. Eukaryotes lack this enzyme, and add pyrophosphate from ATP to unphosphorylated thiamine in a single step.
ReferencesDR EXPERIMENTAL; SP:P77785; Escherichia coli DR OUTGROUP; OMNI|NTL01MT00202; hydrogenase expression/formation protein HypE
Genome PropertyGenProp0254: thiamine: TPP from HMP-PP and HET-P (HMM)