HMM Summary Page: TIGR01383

FunctionDJ-1 family protein
Trusted Cutoff131.25
Domain Trusted Cutoff131.25
Noise Cutoff127.15
Domain Noise Cutoff127.15
Isology Typesubfamily
HMM Length180
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorHaft DH
Entry DateNov 19 2001 2:54PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the DJ-1 clade of the so-called ThiJ/PfpI family of proteins. PfpI, represented by a distinct model, is a putative intracellular cysteine protease. DJ-1 is described as an oncogene that acts cooperatively with H-Ras. Many members of the DJ-1 clade are annotated (apparently incorrectly) as ThiJ, a protein of thiamine biosynthesis. However, published reports of ThiJ activity and identification of a ThiJ/ThiD bifunctional protein describe an unrelated locus mapping near ThiM, rather than the DJ-1 homolog of E. coli. The ThiJ designation for this family may be spurious; the cited paper PMID:8885414 refers to a locus near thiD and thiM in E. coli, unlike the gene represented here. Current public annotation reflects ThiJ/ThiD bifunctional activity, apparently a property of ThiD and not of this locus.
ReferencesRM 9070310 RT DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. RA Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H. RL Biochem Biophys Res Commun. 1997 Feb 13;231(2):509-13.