HMM Summary Page: TIGR01409

AccessionTIGR01409
NameTAT_signal_seq
FunctionTat (twin-arginine translocation) pathway signal sequence
Trusted Cutoff16.70
Domain Trusted Cutoff16.70
Noise Cutoff16.70
Domain Noise Cutoff16.70
Isology Typedomain
HMM Length29
AuthorHaft DH
Entry DateDec 28 2001 2:39PM
Last ModifiedFeb 14 2011 3:27PM
CommentProteins assembled with various cofactors or by means of cytosolic molecular chaperones are poor candidates for translocation across the bacterial inner membrane by the standard general secretory (Sec) pathway. This model describes a family of predicted long, non-Sec signal sequences and signal-anchor sequences (uncleaved signal sequences). All contain an absolutely conserved pair of arginine residues, in a motif approximated by (S/T)-R-R-X-F-L-K, followed by a membrane-spanning hydrophobic region. Members with small amino acid side chains at the -1 and -3 positions from the C-terminus of the model should be predicted to be cleaved as are Sec pathway signal sequences. Members are almost exclusively bacterial, although archaeal sequences are also found. A large fraction of the members of this family may have bound redox-active cofactors.
ReferencesRN [1] RM 8939424 RT A common export pathway for proteins binding complex redox cofactors? RA Berks BC. RL Mol Microbiol 1996 Nov;22(3):393-404 RN [2] RM 10652088 RT The Tat protein export pathway. RA Berks BC, Sargent F, Palmer T. RL Mol Microbiol 2000 Jan;35(2):260-74 DR HAMAP; MF_01630; 90 of 93
Genome PropertyGenProp0127: Tat (Sec-independent) protein export (HMM)
GenProp0127: Tat (Sec-independent) protein export (HMM)
GenProp0127: Tat (Sec-independent) protein export (HMM)