Accession | TIGR01434 |
Name | glu_cys_ligase |
Function | glutamate--cysteine ligase |
Gene Symbol | gshA |
Trusted Cutoff | 393.30 |
Domain Trusted Cutoff | 393.30 |
Noise Cutoff | 223.85 |
Domain Noise Cutoff | 223.85 |
Isology Type | equivalog |
EC Number | 6.3.2.2 |
HMM Length | 512 |
Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
Subrole Category | Glutathione and analogs |
Gene Ontology Term | GO:0004357: glutamate-cysteine ligase activity molecular_function |
| GO:0006750: glutathione biosynthetic process biological_process |
Author | Haft DH |
Entry Date | Feb 4 2002 5:53PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Alternate name: gamma-glutamylcysteine synthetase.
This HMM represents glutamate--cysteine ligase, and enzyme in the biosynthesis of glutathione (GSH). GSH is one of several low molecular weight cysteine derivatives that can
serve to protect against oxidative damage and participate in a biosynthetic or detoxification reactions. |
References | Clostridium acetobutylicum candidate is short, is from an actinomycete (mycothione expected instead), and scores between trusted and noise.
DR HAMAP; MF_00578; 64 of 66 |
Genome Property | GenProp0030: glutathione biosynthesis (HMM) |