HMM Summary Page: TIGR01439

Functiontranscriptional regulator, AbrB family
Trusted Cutoff28.30
Domain Trusted Cutoff28.30
Noise Cutoff26.15
Domain Noise Cutoff26.15
Isology Typedomain
HMM Length44
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0003700: sequence-specific DNA binding transcription factor activity molecular_function
GO:0006355: regulation of transcription, DNA-dependent biological_process
AuthorHaft DH
Entry DateFeb 7 2002 2:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis DNA-binding domain family includes AbrB, a transition state regulator in Bacillus subtilis, whose DNA-binding domain structure in solution was determined by NMR. The domain binds DNA as a dimer in what is termed a looped-hinge helix fold. Some members of the family have two copies of the domain in tandem. The domain is found usually at the N-terminus of a small protein. This model excludes members of family TIGR02609.
ReferencesRM 11101897 RT Novel DNA binding domain and genetic regulation model of Bacillus subtilis transition state regulator abrB. RA Vaughn JL, Feher V, Naylor S, Strauch MA, Cavanagh J. RL Nat Struct Biol 2000 Dec;7(12):1139-46