|Function||methyltransferase, FkbM family|
|Domain Trusted Cutoff||37.70|
|Domain Noise Cutoff||26.30|
|Entry Date||Feb 13 2002 3:17PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.|
RT Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.
RA Motamedi H, Shafiee A, Cai SJ, Streicher SL, Arison BH, Miller RR.
RL J Bacteriol 1996 Sep;178(17):5243-8|
|Genome Property||GenProp0912: Leptospira exopolysaccharide biosynthesis clusters (HMM-CLUST)|
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